Fox, Passman & Fischer all receive Undergraduate Research Opportunity Program (UROP) grants

Three students in the Department of Bioengineering were awarded an Undergraduate Research Opportunity Program (UROP) grant: Thomas Fox, Samantha Passman and William Fischer.

Fox is under the mentorship of Dr. Gibson. His proposal is entitled “Investigating new methods of neural-navigation using Optical Coherence Tomography.”  Both Passman and Fischer are mentored by Dr. Benninger.  Samantha’s proposal is “Blood flow measurement as a tool for measuring inflammation across murine pancreases” and William’s proposal “Investigating Cumulative Effects of Multiple Gene Variants on Type 2 Diabetes Risk Using Computer Modeling”

Congratulations Thomas, Samantha and William!

 

 

Gibson receives National Science Foundation Partnerships for Innovation Award

NSF Partnerships for Innovation: Accelerating Innovation Research-Technology Translation (PFI: AIR-TT) grant was awarded to Emily Gibson to further develop a prototype device for fiber-coupled multiphoton imaging and stimulation of brain activity.  The award supports innovative ideas and partnerships in the translation of NSF-funded fundamental science and engineering discoveries towards market-valued solutions.  The grant will help translate CU technology to the marketplace and will involve a Denver-based company, Intelligence Imaging Innovations (3i).  The technology originated through collaborations between the Department of Bioengineering, CU Boulder ECEE and Mechanical Engineering, and the Neuroscience program at CU Anschutz Medical Campus.

ACS Editor’s Choice features collaboration between Drs. Park and Mestroni

A collaborative research by Drs. Park (Bioengineering) and Mestroni (Cardiovascular Institute), titled “Biomimetic Polymers for Cardiac Tissue Engineering”, was featured as ACS Editor’s Choice. In this research, Dr. Pena (Postdoctoral Researcher) developed a biomimetic injectable system that can increase survival of both neonatal and adult rat ventricular cardiomyocytes (CMs). This research will provide new treatment platform for CM transplantation to repair heart function in a minimally invasive manner.

Biomacromolecule_Editor’s Choice

McIntyre, Rens receive patent

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Professor Rens and Bill Mcintyre at Bill’s dissertation defense.

Bill McIntyre, the college’s first EAS PhD graduate, and civil engineering professor and chair Kevin Rens have received a patent for a System and Method of Using Differential Elevation-Induced Energy for the Purpose of Storing Water Underground. This patent is the result of McIntyre’s dissertation and is a big deal in the water resources field, especially when dealing with alluvial storage and recovery. This is the first patent for both Rens and McIntyre.

Congratulations to both of you!

Bennett named 2016 CEAS Outstanding Staff

Annie Bennett, program assistant for the Department of Electrical Engineering, has been named the 2016 College of Engineering and Applied Science Outstanding Staff. The award, which includes a cash prize as well as a commemorative plaque, will be presented at the college Year-End Celebration on May 13.

As the winner of this year’s award, Sarah will be appointed to serve on the selection committee for next year’s Outstanding Staff award.

Congratulations!

Bioengineering Spring Open House a Success

open house open house-3 open house-2On Friday, April 8, the Department of Bioengineering hosted their spring Open House from 3-6 pm. Nearly 100 people from the community attended, including prospective undergraduate and graduate students, parents, and high school counselors/advisors. The Open House was held in the new Bioscience 2 building on the Anschutz Medical Campus and was laid out to show off the new space and state-of-the-art laboratories.

Attendees walked through the Research Showcase, which featured bioengineering faculty and students from their labs, and the Undergraduate Showcase, which featured undergraduate class projects, the “Ask an Undergrad” table, and 3D bioprinters. There were also scheduled prospective student informational sessions throughout the evening, as well as a prospective student Q & A and a department welcome given by Dr. Kendall Hunter.

Bioengineering, CU Anschutz featured in special Denver Business Journal section

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CU Anschutz Medical Campus. (Photo by Casey A. Cass/University of Colorado)

Last week, the Denver Business Journal published a special section highlighting the Anschutz Medical Campus. The feature titled, “Casual interaction drives Anschutz research” highlights the Bioengineering Department.

Read the story or check out the entire section.

Kheyfets receives ENTELLIGENCE Young Investigator Program grant award

Vitaly Kheyfets, PhD, Assistant Research Professor in the Department of Bioengineering has received an ENTELLIGENCE Young Investigator Program grant for his research titled, Inter-ventricular decoupling is an overlooked contributor to right ventricular myocardial stress and dysfunction in pediatric pulmonary hypertension. Pediatric pulmonary arterial hypertension (PAH) is a degenerative disease that can ultimately lead to right heart failure. Lately, proposed clinical techniques for assessing disease progression and risk stratification have utilized the relative safety of, and abundant information available in, Cardiac MR (CMR) images. These techniques allow for direct functional and morphological measurements, and can be used to perform patient specific computational simulations that compute mechanical stress. Tagged MRI is a relatively new technique that can also reveal strain and local ventricular twisting. This project will combine MR imaging (with and without tissue tagging), computational modeling, and blood biochemical analysis to completely phenotype right ventricular dysfunction in pediatric pulmonary hypertension and improve our understanding of the biomechanical/biochemical progression of the disease.

Right ventricular (RV) dysfunction is commonly attributed to pressure or volume overload, but direct contribution of the left ventricle (LV) is usually overlooked. However, multiple previous studies have shown that the RV is relying on the mechanical energy transfer from LV contraction for up to 80% of its pumping performance. The initial dysfunction of a single ventricle can trigger a remodeling response in the neighboring ventricle, which would further contribute to the dysfunction of the former. Therefore, changes to LV twisting-rate seen in PAH is likely both the cause and effect of ultimate RV dysfunction. The objective of this study is to: (1) provide definitive evidence that LV twisting-rate is decreased in pediatric PAH, which is associated with a decrease in RV contractility; (2) investigate, using computational modeling, if restoring LV twisting-rate would improve RV function; (3) test how restoring LV twisting-rate would impact myocardial stress; and (4) identify imaging and biochemical markers that correlate with LV twisting-rate and are indicative of myocardial stress. The successful completion of these objectives will: (1) lead to novel prognostic markers and a better understanding of the cardio-pulmonary pathophysiology associated with PAH, which would improve our ability to tailor clinical intervention to patient-specific etiology and regularly evaluate therapeutic efficacy; and (2) provide preliminary data for a future studies to investigate the link between functional RV-LV decompensation and changes in gene expression.