Dr. Park, Assistant Professor in the Department of Bioengineering at CU Denver, receives NIH R21 grant ($406,500) from National Heart, Lung, and Blood Institute. His project title is “A biomimetic reverse thermal gel for the treatment of myocardial infarction”. NIH will support this research for two years.
Myocardial infarction (MI) is a leading coronary artery disease caused by the death of heart muscle tissues. The aim of this research is to develop new methodology to treat MI using a synthetic growth factor (GF) delivery system that 1) mimics biofunction of natural heparin, 2) achieves sustained and localized GF expression and 3) promotes angiogenesis in the infarction site and thereby enhances MI treatment effect.
The University of Colorado Technology Transfer Office (TTO) has awarded Daewon Park, Ph.D., an Assistant Professor in the Department of Bioengineering, a State Bioscience Proof of Concept Grant (POCsb) for his proposal to further develop the technology identified to the TTO as Antimicrobial reverse thermal gel for surgical coating.
This proposal aims at developing a polymer-based antimicrobial surgical coating that can act as a surgical incision drape. This polymer is specifically designed to possess a reverse thermal gelling property. It is a water-soluble material and maintains its solution state at low temperature whilst turning into a physical gel upon heating (e.g. upon contact of human skin). This unique property allows the product to be easily sprayed on the patient’s skin and form a layer of antimicrobial gel on the skin surface. During the surgery the gel might dry out and form a film on the skin; however, the film will maintain its antimicrobial activity during the entire surgical process. Moreover, since the polymer returns to solution state at low temperature, it can be easily removed by washing with cold water (or cold alcohol) without the risk of epidermal cell layer detachment. Some may worry that the gel may be solubilized during the surgery by body fluid (e.g., blood); however, once the gel is formed, it only returns to a liquid state in a low temperature environment (<~15oC).
Jeff Cozart explains what research the University of Colorado Denver is conducting and why it will be critical for our students in the future.
Video provided by the University of Colorado Denver | Anschutz Medical Campus