This August the department of Bioengineering hosted its first ever Bioengineering Opportunities and Leadership Training (BOLT) for high school students. 25 students from around the metro area participated in the week’s activities, which ranged from building an optical heart rate monitor and learning about tissue engineering to visiting the Children’s Hospital Gait Lab and Center for Surgical Innovation. The objective of the camp was to expose students to the many different facets of bioengineering and to get them excited about what a career as a biomedical engineer could look like. At the conclusion of the week students presented their rough prototypes of new designs for medical devices that could help a pediatrician before enjoying an ice cream social with the students and faculty of the BIOE Department.
CU Anschutz and CU Boulder scientists to use unique microscope for high risk brain research
AURORA, Colo. (August 18, 2016) – Researchers from the University of Colorado Anschutz Medical Campus and the University of Colorado Boulder have won a $800,000 grant from the National Science Foundation to try and reconnect neural communication between parts of the brain where it has been severed.
If successful, this could have major implications for those suffering brain injury, stroke, Parkinson’s disease and other neurological problems.
The team of neuroscientists and engineers will use a special lightweight microscope, which they designed, to peer into and control the living brain of a mouse as they try to reconnect parts of the brain that no longer communicate with each other.
The miniature microscope, using a unique electrowetting lens, is mounted on the head of a mouse and with its high-powered, fiber-optic light can actually view and control neural activity as it happens.
“Adaptive optical devices that are included in a miniature microscope are a game changer,” said grant co-investigators Juliet Gopinath, assistant professor in electrical, computer and energy engineering and Victor Bright, professor of mechanical engineering, both at CU Boulder. “They enable truly miniature 3D imaging devices without mechanically moving parts.”
According to Gopinath and Bright, the electrowetting lens is compact, low power and has good optical quality making it ideal for this kind of research. The liquid lens can change shape when voltage is applied.
The team will use an optic fiber to disrupt the signals between the olfactory bulb of a mouse, which receives information on odors, and the olfactory cortex, the part of the brain that allows it to smell. In essence, they will shut down its ability to smell and then try to restore it by activating the olfactory cortex using the miniature microscope.
The mouse will be awake and behaving normally throughout this while the team views and controls what is happening in the brain with the electrowetting fiber-coupled microscope. They can stimulate the animal’s brain activity using powerful laser light that flows through the microscope’s fiber-optic bundle.
“One major problem with the brain is that with certain diseases or injuries, one part of the brain stops talking to another,” said co-investigator Diego Restrepo, professor of cell and developmental biology and director of the Center for NeuroScience at the University of Colorado School of Medicine. “If someone has a stroke they may no longer be able to speak.”
Once connections between brain areas are lost, it is difficult to get them communicating again.
Restrepo said if researchers are successful reestablishing brain connections in a mouse, they may be able do the same in humans with brain injury or disease.
“For example, if there is loss of connection between the retina that detects the image in the eyes and the visual cortex, in the back of the brain the patient has a problem detecting images that in the worst case leads to blindness,” Restrepo said. “That loss of connection between the retina and visual cortex can be due to neural problems such as stroke, neuro-immune disease or traumatic brain injury.”
If this experiment is successful, he said, this microscope could eventually be modified to activate neurons in the visual cortex based on the visual input. In other words, creating a bridge between two parts of the brain where communication has stopped.
“This is an interdisciplinary grant which combines bioengineering with neurological applications,” said Emily Gibson, assistant professor of bioengineering at CU Anschutz. “The idea is to use this device which can image individual neurons and stimulate those individual neurons in that 3D volume.”
She also noted that two of the principal investigators on the grant are women, a rarity in the field of engineering.
“This particular grant is for high risk, high payoff approaches,” she said. “And this is a very high risk project. We are pushing the technology farther and seeing if we can use these optical tools to ultimately make an impact on humans.”
The grant is funded under a program from the National Science Foundation known as the “Integrative Strategies for Understanding Neural and Cognitive Systems (NSF-NCS).”
It is one element of NSF’s broader effort directed at Understanding the Brain, (http://www.nsf.gov/brain/) a multi-year activity that includes NSF’s participation in the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative.
The team also won a second NSF grant of $200,000 to be used in the dissemination and commercialization of its microscope.
On Friday, April 8, the Department of Bioengineering hosted their spring Open House from 3-6 pm. Nearly 100 people from the community attended, including prospective undergraduate and graduate students, parents, and high school counselors/advisors. The Open House was held in the new Bioscience 2 building on the Anschutz Medical Campus and was laid out to show off the new space and state-of-the-art laboratories.
Attendees walked through the Research Showcase, which featured bioengineering faculty and students from their labs, and the Undergraduate Showcase, which featured undergraduate class projects, the “Ask an Undergrad” table, and 3D bioprinters. There were also scheduled prospective student informational sessions throughout the evening, as well as a prospective student Q & A and a department welcome given by Dr. Kendall Hunter.