Pulmonary Hypertension is a progressive disease that ultimately leads to right heart failure. This K25 award looks at the mechanical and biochemical interaction between the right and left heart, during the progression of this cardio-pulmonary disease. Both sides of the heart are both moving “pumps” that are physically connected to one another. The study utilizes magnetic resonance imaging, computational modeling, and gene expression analysis of animal tissue to establish two key concepts: (1) declining right heart function during pulmonary hypertension can be improved by targeting the left heart; and (2) the left heart can be targeted through genes that control the contraction speed of the left heart muscle. If this approach proves to be successful, it could lead to novel therapies for treating right heart failure in children with pulmonary hypertension.